September 21, 2018BMC Veterinary ResearchOpen Access

Safety and immunogenicity of an attenuated Chinese pseudorabies variant by dual deletion of TK&gE genes

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Why the study?

Does the PRV ΔTK&gE-AH02 vaccine candidate provide safe and effective protection against virulent pseudorabies virus challenge in piglets?

Structured PICO

Does the PRV ΔTK&gE-AH02 vaccine candidate provide safe and effective protection against virulent pseudorabies virus challenge in piglets?

Population

Mice and piglets (1-day-old with or without maternal PRV antibodies, and 28~35-day-old without maternal PRV antibodies)

Intervention

PRV ΔTK&gE-AH02 (a TK&gE dual deficient mutant pseudorabies virus) administered nasally or intramuscularly at doses ranging from 10^3.0 to 10^6.0 TCID50

Comparator

Unvaccinated challenge control and PRV Bartha K61 vaccine

Outcome

Safety (clinical signs, death, virus shedding) and protection against virulent PRV challengesafety

The PRV ΔTK&gE-AH02 mutant is a safe and highly immunogenic vaccine candidate that provides complete clinical protection and stops virus shedding against the emerging PRV variant in pigs.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

TK/gE-deficient PRV mutant offers a balanced vaccine candidate; leaves open in vivo safety and efficacy trials in pigs.

Cite This Study

Wang et al. (2018) studied this question.

synapsesocial.com/papers/6a719c34febe604dd70a31df https://doi.org/10.1186/s12917-018-1536-7

View Full Paper

Ask AI

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Safety and immunogenicity of an attenuated Chinese pseudorabies variant by dual deletion of TK&gE genes

Structured PICO

Discussion

Implication

Cite This Study

Safety and immunogenicity of an attenuated Chinese pseudorabies variant by dual deletion of TK&gE genes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider