October 4, 2011Journal of Hypertension

Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin–angiotensin–aldosterone system activity and the efficacy of renin–angiotensin–aldosterone system blockade in the kidney

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Population

101 diabetic and nondiabetic patients with or without hypertension

Design

Cross-sectional

Authors

MHMieke van den Heuvel WBWendy W. Batenburg SJSjaam Jainandunsing

Discussion

Member takes

Overview

Urinary renin may better indicate renal RAAS suppression by ACEi/ARBs than other markers in diabetes; hypothesis-generating for biomarker use pending prospective validation.

Structured PICO

Population

101 diabetic and nondiabetic patients with or without hypertension

Intervention

Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARB)

Outcome

Urinary and plasma levels of renin, prorenin, angiotensinogen, aldosterone, albumin, and creatininesurrogate

Urinary renin is a more accurate biomarker for assessing renal RAAS activity and the local efficacy of RAAS blockade than urinary angiotensinogen or aldosterone.

Cite This Study

Heuvel et al. (2011) studied this question.

synapsesocial.com/papers/6a719c58f44fa9f079df606c https://doi.org/10.1097/hjh.0b013e32834bbcbf

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October 4, 2011Journal of Hypertension

Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin–angiotensin–aldosterone system activity and the efficacy of renin–angiotensin–aldosterone system blockade in the kidney

View Full Paper

Ask AI

Bookmark

Population

101 diabetic and nondiabetic patients with or without hypertension

Design

Cross-sectional

Authors

MHMieke van den Heuvel WBWendy W. Batenburg SJSjaam Jainandunsing

Discussion

Member takes

Overview

Urinary renin may better indicate renal RAAS suppression by ACEi/ARBs than other markers in diabetes; hypothesis-generating for biomarker use pending prospective validation.

Structured PICO

Population

101 diabetic and nondiabetic patients with or without hypertension

Intervention

Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARB)

Outcome

Urinary and plasma levels of renin, prorenin, angiotensinogen, aldosterone, albumin, and creatininesurrogate

Urinary renin is a more accurate biomarker for assessing renal RAAS activity and the local efficacy of RAAS blockade than urinary angiotensinogen or aldosterone.

Cite This Study

Heuvel et al. (2011) studied this question.

synapsesocial.com/papers/6a719c58f44fa9f079df606c https://doi.org/10.1097/hjh.0b013e32834bbcbf

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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