CD4+ T cells in cancer

This is the authors' abstract. We don't add key points for this paper.

Cancer immunology and immunotherapy are driving forces of research and development in oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent progress highlights the importance of CD4+ T cells, corresponding to the long-known fact that CD4+ T cells are central players and coordinators of innate and antigen-specific immune responses. Moreover, they have now been recognized as anti-tumor effector cells in their own right. Here we review the current status of CD4+ T cells in cancer, which hold great promise for improving knowledge and therapies in cancer. Speiser and colleagues review the latest advances in understanding of the biological roles of CD4+ T cells in cancer immunology and applications for immunotherapy.