Key result
Cheyne-Stokes respiration is not associated with quality of life or symptoms in stable HF.
Cross-Sectional (n=182)
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Reveals Cheyne-Stokes respiration does not worsen quality of life or daytime sleepiness in stabilized heart failure patients, suggesting standard symptoms may fail to detect central sleep apnea.
BACKGROUND AND AIMS: The effects of central sleep apnea in Cheyne-Stokes respiration on sleep-related symptoms and quality of life are not very well established. We aimed to investigate whether Cheyne-Stokes respiration is related to health-related quality of life. We also studied the impact on daytime sleepiness and nocturnal dyspnea. METHODS: Included were 203 consecutive patients, stabilized following in-hospital treatment for decompensated congestive heart failure. They underwent overnight cardiorespiratory sleep apnea recordings in hospital and answered a set of questions on symptoms and health-related quality of life questionnaires in the form of the Nottingham Health Profile and the Minnesota Living with Heart Failure Questionnaire. After excluding seven patients with predominantly obstructive apneas and 14 with insufficient recordings, 182 patients were included in the final analysis. RESULTS: One third of the patients had an apnea-hypopnea index (AHI) of >30. Falling asleep in front of the television was the only symptom related to (AHI). Nocturnal dyspnea, daytime sleepiness, generic quality of life or disease-specific quality of life were not related to AHI. CONCLUSIONS: Cheyne-Stokes respiration was not associated with health-related quality of life, daytime sleepiness or nocturnal dyspnea among patients stabilized following treatment for congestive heart failure.
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Midgren et al. (2009) conducted a cross-sectional in Decompensated congestive heart failure (n=182). Cheyne-Stokes respiration (assessed via apnea-hypopnea index) vs. Lower or absent apnea-hypopnea index was evaluated on Health-related quality of life (Nottingham Health Profile and Minnesota Living with Heart Failure Questionnaire), daytime sleepiness, and nocturnal dyspnea. Cheyne-Stokes respiration (AHI >30 in 33% of 182 stabilized heart failure patients) was not associated with quality of life, daytime sleepiness, or nocturnal dyspnea.
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