Key result
Female sex linked to ~16-point lower CVD prevalence in long-standing type 1 diabetes.
Cross-Sectional (n=680)
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Two recent articles describe higher morbidity and mortality from cardiovascular disease (CVD) at younger ages for women with type 1 diabetes compared with men in cohorts with average duration of approximately 30 years (1,2). Women in the Joslin 50-Year Medalist Study (total n = 680) have a significantly lower CVD prevalence than men (women 35.3% vs. men 51.6%, P < 0.001), suggesting a protective factor. The objective of this analysis was to investigate protective factors associated with CVD and sex-associated differences in rates in those with long-term type 1 diabetes. The Joslin 50-Year Medalist Study is a cross-sectional study of individuals with 50 or more years of type 1 diabetes ( n = 651). To be awarded the Joslin 50-Year Medal, individuals provide an original medical record from time of diagnosis, or three other forms of documentation of insulin dependence since the time of diagnosis 50 or more …
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He et al. (2015) conducted a cross-sectional in Long-duration type 1 diabetes and cardiovascular disease (n=680). Female sex vs. Male sex was evaluated on Cardiovascular disease prevalence (p=<0.001). Women with ≥50 years of type 1 diabetes had a significantly lower prevalence of cardiovascular disease than men (35.3% vs. 51.6%, P<0.001).
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