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Asperlicin(1), a competitive cholecystokinin (CCK) antagonist, produced from Aspergillus alliaceus, was originally characterized primarily by means of X-ray crystallography.1~3)The compound contains a 1,4-benzodiazepine ring with a quinazolone fused to the 1,2-positions, and a 3substituted moiety condensed from tryptophan and leucine.This was the first reported naturally occurring nonpeptide antagonist of a peptide receptor.Subsequently, several possible therapeutically useful CCK antagonists were synthesized
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Sun et al. (1994) studied this question.
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