Population
Human muscle ClC-1 chloride channels transiently expressed in human embryonic kidney (HEK 293) cells
Design
Preclinical
Authors
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Indicates distinct ClC-1 slow gating mechanism; leaves open relevance to human muscle excitability and channelopathies.
The temperature sensitivity of the slow gate implies that the slow gating of ClC-1 is mechanistically different from that of ClC-0.
Bennetts et al. (2001) studied this question.
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