More than skin-deep: Synthetic skin-permeable antigens are constructed by conjugation of the cell-penetrating low-molecular-weight protamine (LMWP) peptide to protein antigens through cleavable disulfide bonds. Such artificial antigens can penetrate the stratum corneum barrier (see picture), thereby sensitizing the skin immune system to elicit robust immune responses.
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Huang et al. (2010) studied this question.
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