January 1, 2015Thrombosis and Haemostasis
Antiplatelet drugs in patients with enhanced platelet turnover: biomarkers versus platelet function testing
Population
Patients with atherothrombotic disease, with a focus on acute coronary syndromes, particularly those with…
Design
Review
Authors
Discussion
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Implication
Reticulated platelets may aid prognostication in atherothrombosis; leaves open whether targeting turnover improves outcomes.
Structured PICO
P
Population
Patients with atherothrombotic disease, with a focus on acute coronary syndromes, particularly those with enhanced platelet turnover.
I
Intervention
Antiplatelet therapy (aspirin alone or with P2Y12-inhibitors)
Enhanced platelet turnover, estimated by reticulated platelets, may play a key role in the pathogenesis of atherothrombotic diseases and contribute to high on-treatment platelet reactivity.
Cite This Study
Gruber et al. (2015) studied this question.