Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2005Blood Coagulation & Fibrinolysis

Platelet hyper-function in acute coronary syndromes

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does platelet function and von Willebrand factor level differ in patients with acute coronary syndromes compared to healthy subjects after aspirin administration?

Population

78 patients presenting with acute chest pain and 20 healthy normal subjects.

Comparison

Aspirin 300 mg administered more than 2 hours… vs Healthy normal subjects, 10 of whom were tested…

Design

Cross-sectional

Authors

PHPaul HarrisonCross-Cutting CardiologyIMIan MackieUniversity College LondonAMAnthony MathurInterventional / Structural Cardiology

Discussion

Loading...

Member takes

Implication

May underlie aspirin hyporesponsiveness in MI; hypothesis-generating and requires prospective validation.

Structured PICO

Does platelet function and von Willebrand factor level differ in patients with acute coronary syndromes compared to healthy subjects after aspirin administration?

P
Population
78 patients presenting with acute chest pain (classified into myocardial infarction, unstable angina, and non-specific chest pain) and 20 healthy normal subjects.
I
Intervention
Aspirin 300 mg administered more than 2 hours before blood collection
C
Comparator
Healthy normal subjects (n=20), 10 of whom were tested before and 2 hours after 300 mg aspirin
O
Outcome
Platelet function measured by PFA-100 (collagen/adenosine diphosphate and collagen/epinephrine closure times) and von Willebrand factor levelssurrogate

Patients with myocardial infarction exhibit platelet hyper-function and elevated von Willebrand factor levels, which may explain decreased in vitro responsiveness to aspirin.

Cite This Study

Harrison et al. (2005) studied this question.

synapsesocial.com/papers/6a71a4285d37378ac1debd19https://doi.org/10.1097/01.mbc.0000187252.09759.ba

Topics

Dual antiplatelet therapy
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Function Predicts Myocardial Damage in Patients With Acute Myocardial Infarction2004 · 256 citations
  2. 2Differences in bleeding time, aspirin sensitivity and adrenaline between acute myocardial infarction and unstable angina1990 · 48 citations
  3. 3Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA2005 · 71 citations
  4. 4Performance of the platelet function analyser PFA-100?? in testing abnormalities of primary haemostasis1999 · 172 citations
  5. 5Monitoring of Aspirin (ASA) Pharmacodynamics with the Platelet Function Analyzer PFA-100®2000 · 201 citations