Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1993British journal of surgery

Low-dose aspirin fails to inhibit increased platelet reactivity in patients with peripheral vascular disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does low-dose aspirin (75 mg/day) inhibit platelet reactivity in patients with advanced peripheral vascular disease requiring surgery?

Population

31 patients with advanced peripheral vascular disease requiring surgery, and 30 age- and sex-matched controls.

Comparison

Low-dose aspirin administered perioperatively. vs Age- and sex-matched controls and pre-aspirin…

Design

Cohort

Follow-up

1 week after surgery

Authors

TWT K WaltersSt Bartholomew's HospitalDMDavid C. MitchellNorth Bristol NHS TrustRWR. F. M. WoodNova Scotia Health Authority

Discussion

Loading...

Member takes

Implication

Low-dose aspirin may fail to inhibit platelet reactivity in advanced PVD; leaves open whether alternative perioperative regimens merit prospective testing.

Key Points

  • To assess the inhibitory efficacy of low-dose aspirin (75 mg/day) on heightened platelet reactivity in patients undergoing surgery for advanced peripheral vascular disease.
  • Measured shear-induced haemostasis and collagen-induced thrombus formation in non-anticoagulated fresh whole blood using an ex vivo haemostatometer in 31 surgical patients with advanced peripheral vascular disease and 30 age- and sex-matched controls.
  • Evaluated platelet reactivity longitudinally in 18 patients before aspirin administration and one week after surgery while receiving 75 mg/day aspirin.
  • Shear-induced haemostasis was significantly accelerated in patients with peripheral vascular disease compared to controls, with index values of mean(s.e.m.) 1977(180) mmHg s versus 3161(234) mmHg s (P < 0.001).
  • Collagen-induced thrombus formation occurred significantly faster in patients than in controls, with index values of mean(s.e.m.) 3980(460) mmHg s versus 5350(420) mmHg s (P = 0.02).
  • Perioperative treatment with 75 mg/day aspirin failed to significantly inhibit platelet reactivity in patients with peripheral vascular disease.

Structured PICO

Does low-dose aspirin (75 mg/day) inhibit platelet reactivity in patients with advanced peripheral vascular disease requiring surgery?

P
Population
31 patients with advanced peripheral vascular disease requiring surgery, and 30 age- and sex-matched controls.
I
Intervention
Low-dose aspirin (75 mg/day) administered perioperatively.
C
Comparator
Age- and sex-matched controls (for baseline comparison) and pre-aspirin baseline (within-subject comparison in 18 patients).
O
Outcome
Platelet reactivity measured by shear-induced haemostasis and collagen-induced thrombus formation in non-anticoagulated fresh whole blood samples ex vivo.surrogate

Low-dose aspirin (75 mg/day) is ineffective at inhibiting the heightened platelet reactivity observed in patients with advanced peripheral vascular disease undergoing surgery.

Cite This Study

Walters et al. (1993) studied this question.

synapsesocial.com/papers/6a71a4285d37378ac1debd1ehttps://doi.org/10.1002/bjs.1800801014
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aspirin and dipyridamole in the prevention of acute coronary thrombosis complicating coronary angioplasty.1987 · 325 citations
  2. 2Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina1983 · 1,713 citations
  3. 3A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro1974 · 1,855 citations
  4. 4High-dose aspirin inhibits shear-induced platelet reaction involving thrombin generation.1992 · 152 citations
  5. 5Random control trial of a short course of aspirin and dipyridamole (Persantin) for femorodistal grafts1987 · 89 citations