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January 1, 1990The International Journal Of Cell Cloning

The control of megakaryocyte ploidy and platelet production: Biology and pathology

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Population

Animals (rats, rabbits) and human patients with myocardial infarction or lymphoma

Comparison

Various experimental stimuli vs Controls

Design

Review

Authors

AGA. M. GladwinKing's College SchoolJMJohn F. MartinHenry Smith Charity

Discussion

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Overview

Hypothesis-generating for separate hormonal control of MPV and megakaryocyte ploidy in MI; prospective validation required before clinical consideration.

Structured PICO

P
Population
Animals (rats, rabbits) and human patients with myocardial infarction or lymphoma
I
Intervention
Various experimental stimuli (vincristine, chronic hypoxia, anti-platelet serum, cholesterol feeding)
C
Comparator
Controls
O
Outcome
Mean platelet volume and megakaryocyte DNA content/ploidysurrogate

The review suggests that mean platelet volume and megakaryocyte ploidy are under separate hormonal control, both of which are stimulated during myocardial infarction.

Cite This Study

Gladwin et al. (1990) studied this question.

synapsesocial.com/papers/6a71a4285d37378ac1debd22https://doi.org/10.1002/stem.5530080414
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Production in Myocardial Infarction and Sudden Cardiac Death1984 · 74 citations
  2. 2Platelet size in myocardial infarction.1983 · 178 citations
  3. 3The Platelet Volume Distribution: A Signature of the Prethrombotic State in Coronary Heart Disease?1987 · 52 citations
  4. 4Occurrence of Megakaryocytes in Various Vessels and Their Retention in the Pulmonary Capillaries in Man1978 · 101 citations
  5. 5Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man1987 · 53 citations