Much has been learned about tissue factor during the past 25 years and much is yet to be learned. On the biochemical level, the association of TF:VIIa with factor X is yet to be resolved. The mechanism by which TF is transported from the nucleus to the plasma membrane has yet to even be approached. Thus, those of us studying this interesting and fundamentally important molecule have much work in the future.
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Yale Nemerson (1995) studied this question.