Why the study?
Does TRPC5 deletion cause obesity and postpartum depression in humans and mouse models?
Population
Humans carrying TRPC5 deletions on chromosome Xq23 and knockin mice with a human loss-of-function TRPC5 mutation
Comparison
TRPC5 deletion or loss-of-function vs controls and Trpc5 overexpression rescue
Design
Translational genetic and preclinical knockin mouse study
Authors
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May link TRPC5 to human obesity and autism traits; leaves open therapeutic targeting pending further study.
Does TRPC5 deletion cause obesity and postpartum depression in humans and mouse models?
TRPC5 plays a pivotal role in mediating innate human behaviors fundamental to survival, including food seeking and maternal care.
Li et al. (2024) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: