Why the study?
Although statins are widely used for stroke prophylaxis, poststroke statin use may lead to depressive changes, leaving the effect of statin timing—particularly prestroke—unclear.
Does statin treatment alter the risk of poststroke depression in patients with first-ever ischemic stroke?
Does statin treatment alter the risk of poststroke depression in patients with first-ever ischemic stroke?
Continuous statin therapy before and after an ischemic stroke is associated with an increased risk of poststroke depression compared to no statin therapy.
No takes yet. Share an insight, caveat, or question.
Timing of statin use around stroke may affect PSD risk; hypothesis-generating and should not yet change practice.
Li et al. (2021) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: