Key result
Anti-inflammatory treatment with ASA, NSAIDs, or statins after stroke decreased the risk for early-onset depression, but ASA or NSAIDs increased the risk for late-onset depression.
Why the study?
Does anti-inflammatory treatment (ASA, NSAIDs, or statins) reduce the risk of depression in patients with first-time stroke?
Cohort (n=307,722)
Does anti-inflammatory treatment (ASA, NSAIDs, or statins) reduce the risk of depression in patients with first-time stroke?
Anti-inflammatory treatments such as ASA, NSAIDs, and statins are associated with a reduced risk of early-onset depression after stroke, but ASA and NSAIDs may increase the risk of late-onset depression.
No takes yet. Share an insight, caveat, or question.
Should not yet change post-stroke prescribing; leaves open causal timing effects for RCTs.
Wium‐Andersen et al. (2017) conducted a cohort in Stroke (n=307,722). Anti-inflammatory treatment (ASA, NSAIDs, or statins) vs. No anti-inflammatory treatment was evaluated on Early-onset (≤ 1 year) and late-onset (> 1 year) depression. Anti-inflammatory treatment with ASA, NSAIDs, or statins after stroke decreased the risk for early-onset depression, but ASA or NSAIDs increased the risk for late-onset depression.
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