Key result
Statin therapy at discharge after a cardiac event was associated with a 69% reduced likelihood of developing depression at 3 months (OR 0.31; 95% CI 0.097-0.972; P=0.045).
Why the study?
Does statin therapy reduce the risk of subsequent depression in patients hospitalized for a cardiac event or intervention?
Population
193 patients hospitalized for angioplasty, myocardial infarction, or coronary artery bypass graft surgery at…
Comparison
Statin therapy at discharge vs No statin therapy at discharge
Design
Cohort
Follow-up
9 months
Authors
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May lower early post-event depression risk; leaves open causality and need for RCTs before practice change.
Cohort (n=193)
No
Does statin therapy reduce the risk of subsequent depression in patients hospitalized for a cardiac event or intervention?
Odds Ratio: 0.31 (95% CI 0.097–0.972)
p-value: p=.045
Statin use after a cardiac event or intervention is associated with a significantly reduced risk of developing depression up to 9 months post-discharge.
Stafford et al. (2010) conducted a cohort in Cardiac event or intervention (n=193). Statin therapy vs. No statin therapy was evaluated on Development of depression at 3 months postdischarge (OR 0.31, 95% CI 0.097-0.972, p=.045). Statin therapy at discharge after a cardiac event was associated with a 69% reduced likelihood of developing depression at 3 months (OR 0.31; 95% CI 0.097-0.972; P=0.045).
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