February 20, 2012The Journal of Clinical Psychiatry
Statin Use and Risk of Depression in Patients With Coronary Heart Disease
Key result
Baseline statin use in patients with coronary heart disease was associated with a 38% decreased odds of subsequent depression (adjusted OR 0.62; 95% CI 0.41-0.95; P=0.02).
Why the study?
Does statin use reduce the risk of depressive symptoms in outpatients with coronary heart disease?
Population
965 outpatients with coronary disease from 12 outpatient clinics in the San Francisco Bay Area
Comparison
Statin use at baseline (2000-2002) vs No statin use at baseline
Design
Cohort
Follow-up
6 years
Authors
Discussion
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Member takes
Implication
Statin use may lower depression risk in CHD outpatients but should not change practice; leaves open need for RCTs to test causality.
Study Design
Type
Cohort (n=965)
Multicenter
Yes
Structured PICO
Does statin use reduce the risk of depressive symptoms in outpatients with coronary heart disease?
P
Population
965 outpatients with coronary heart disease from 12 clinics in the San Francisco Bay Area, followed for 6 years.
E
Exposure
Statin use at baseline (2000-2002)
C
Comparator
No statin use at baseline
O
Outcome
Depressive symptoms assessed annually for 6 years using the Patient Health Questionnaire (PHQ)patient reported
Main Result
Odds Ratio: 0.62 (95% CI 0.41–0.95)
Absolute Event Rate: 28% vs 40%
p-value: p=0.02
In outpatients with coronary heart disease, baseline statin use is associated with a significantly lower risk of developing depressive symptoms over 6 years of follow-up.
Cite This Study
Otte et al. (2012) conducted a cohort in Coronary heart disease (n=965). Statin use vs. Nonusers was evaluated on Depressive symptoms (PHQ score ≥ 10) during follow-up (adjusted OR 0.62, 95% CI 0.41-0.95, p=0.02). Baseline statin use in patients with coronary heart disease was associated with a 38% decreased odds of subsequent depression (adjusted OR 0.62; 95% CI 0.41-0.95; P=0.02).