October 8, 2008Journal of Molecular BiologyOpen Access

Myosin Binding Protein C Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure and Interactions of Domain C1

View Full Paper

Ask AI

Bookmark

Population

In vitro model studying domain C1 of Myosin binding protein C (MyBP-C)

Design

Preclinical

Authors

AAAbdessamad AbabouKing's College London ERElena RostkovaKing's College London SMShreena MistryUniversity of California, Irvine

Discussion

Member takes

Implication

May inform HCM molecular models; hypothesis-generating for zinc modulation of MyBP-C, pending in vivo validation.

Structured PICO

Population

In vitro model studying domain C1 of Myosin binding protein C (MyBP-C)

Intervention

Site-directed mutagenesis and NMR interaction experiments

Outcome

Structure and binding properties of domain C1surrogate

Domain C1 of MyBP-C binds near the S1-S2 hinge and contains a zinc binding site where a hypertrophic cardiomyopathy-related mutation (Q210H) increases affinity, suggesting a mechanism for regulating myosin head positions.

Cite This Study

Ababou et al. (2008) studied this question.

synapsesocial.com/papers/6a71a87ca528af2d65c42a2d https://doi.org/10.1016/j.jmb.2008.09.065

View Full Paper

Ask AI

Bookmark

Myosin Binding Protein C Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure and Interactions of Domain C1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myosin Binding Protein C Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure and Interactions of Domain C1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider