October 26, 2011Circulation Arrhythmia and Electrophysiology
Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization
Population
50 patients with idiopathic ventricular fibrillation associated with early repolarization and 250 age- and…
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
Supports SCN5A-related conduction slowing in idiopathic VF with early repolarization; hypothesis-generating and should not yet change practice.
Structured PICO
P
Population
50 patients with idiopathic ventricular fibrillation associated with early repolarization (44 men; age, 45 ± 17 years) and 250 age- and sex-matched healthy controls.
C
Comparator
250 age- and sex-matched healthy controls
O
Outcome
Electrocardiographic characteristics and presence of SCN5A mutationssurrogate
Loss-of-function mutations in SCN5A and reduced cardiac conduction are associated with idiopathic ventricular fibrillation and early repolarization, supporting the role of decreased sodium current in VF susceptibility.
Cite This Study
Watanabe et al. (2011) studied this question.