This study demonstrates that angiotensinogen is synthesized by astrocytes in the brain, distinguishing it from other known neuropeptide precursors.
Supports astrocytic angiotensinogen synthesis in rodent brain; leaves open human RAS relevance and cardiovascular translation.
Cell types associated with angiotensinogen mRNA in rat brain were identified in individual brain sections by in situ hybridization with tritiated RNA probes or with a sulfur-35--labeled oligonucleotide combined with immunocytochemical detection of either glial fibrillary acidic protein (GFAP) for astrocytes or microtubule-associated protein (MAP-2) for neurons. Autoradiography revealed silver grains clustered primarily over GFAP-reactive soma and processes; most grain clusters were not associated with MAP-2--reactive cells. These results demonstrate that, in contrast to other known neuropeptide precursors, angiotensinogen is synthesized by glia.
No takes yet. Share an insight, caveat, or question.
Stornetta et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: