March 25, 2011Molecular & Cellular ProteomicsOpen Access

Quantitative N-linked Glycoproteomics of Myocardial Ischemia and Reperfusion Injury Reveals Early Remodeling in the Extracellular Environment

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Population

ex vivo rat left ventricular myocardium

Design

Preclinical

Authors

BPBenjamin L. ParkerThe University of Melbourne GPGiuseppe PalmisanoUniversidade de São Paulo AEAlistair V.G. EdwardsUniversity of Southern Denmark

Discussion

Member takes

Implication

Supports earlier ECM involvement in reperfusion than hypothesized; hypothesis-generating in animal models and leaves open human translation.

Structured PICO

Population

ex vivo rat left ventricular myocardium

Intervention

prolonged ischemia and reperfusion (40 mins ischemia and 20 mins reperfusion)

Outcome

changes in glycoproteins from tissue following prolonged ischemia and reperfusionsurrogate

Cardiac remodeling involving extracellular matrix and basement membrane proteins is initiated earlier during reperfusion than previously hypothesized.

Cite This Study

Parker et al. (2011) studied this question.

synapsesocial.com/papers/6a71a97fac440176ef2a46db https://doi.org/10.1074/mcp.m110.006833

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Implication

Supports earlier ECM involvement in reperfusion than hypothesized; hypothesis-generating in animal models and leaves open human translation.

Quantitative N-linked Glycoproteomics of Myocardial Ischemia and Reperfusion Injury Reveals Early Remodeling in the Extracellular Environment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Quantitative N-linked Glycoproteomics of Myocardial Ischemia and Reperfusion Injury Reveals Early Remodeling in the Extracellular Environment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider