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November 1, 1972CirculationOpen Access

Serial Determination of Plasma Catecholamines in Myocardial Infarction

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Why the study?

Does plasma catecholamine concentration correlate with ventricular arrhythmias in patients with acute myocardial infarction?

Population

n=10 patients during the first 48 hours of acute myocardial infarction

Design

Cohort

Follow-up

48 hours

Authors

JVJørgen VidebækCopenhagen University HospitalNCNiels Juel ChristensenUniversity of Wisconsin–MadisonBSB SterndorffAarhus University

Discussion

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Implication

No temporal link challenges catecholamines as direct arrhythmia triggers in AMI; hypothesis-generating for alternative mechanisms.

Key Points

  • To measure serial plasma catecholamine concentrations during the first 48 hours of acute myocardial infarction and determine their temporal relationship to ventricular arrhythmias.
  • Measured plasma catecholamine concentrations at 2-hour intervals during the first 48 hours of acute myocardial infarction in 10 patients.
  • Quantified hormone levels using a double-isotope derivative technique.
  • Tracked heterotopic ventricular activity and compared catecholamine profiles between untreated patients and those receiving antiarrhythmic treatment on admission.
  • Plasma catecholamine concentrations were elevated across most patients to variable degrees, remaining relatively stable within each patient over the 48-hour period.
  • Patients receiving antiarrhythmic treatment on admission exhibited higher plasma catecholamine concentrations than untreated patients.
  • No temporal correlation was observed between plasma catecholamines and ventricular arrhythmias, as heterotopic ventricular activity resolved spontaneously despite steady hormone levels, which remained well below experimental arrhythmogenic thresholds.

Structured PICO

Does plasma catecholamine concentration correlate with ventricular arrhythmias in patients with acute myocardial infarction?

P
Population
n=10 patients during the first 48 hours of acute myocardial infarction
I
Intervention
Serial measurement of plasma catecholamine concentration at 2-hour intervals
O
Outcome
Plasma catecholamine concentration and its correlation with clinical state and ventricular arrhythmiassurrogate

In acute myocardial infarction, plasma catecholamine levels are elevated but do not temporally correlate with ventricular arrhythmias, suggesting they may not be the direct cause of these arrhythmias at the observed concentrations.

Cite This Study

Videbæk et al. (1972) studied this question.

synapsesocial.com/papers/6a71a9bffebe604dd70a3885https://doi.org/10.1161/01.cir.46.5.846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Catechol Amine Concentrations in Myocardial Infarction and Angina Pectoris1959 · 207 citations
  2. 2Urinary Excretion of Catecholamines and their Main Metabolites after Myocardial Infarction; Relationship to the Clinical Syndrome1970 · 33 citations
  3. 3Catecholamine Excretion in Myocardial Infarction1968 · 56 citations
  4. 4General Characteristics of Sympathetic Activity in Human Skin Nerves1972 · 693 citations
  5. 5Serial plasma adrenaline and noradrenaline levels in myocardial infarction using a new double isotope technique.1971 · 60 citations