Why the study?
Sympathetic overactivation causes cardiotoxicity via norepinephrine, but the action of bucindolol on oxidative stress, hypertrophy, and cell death pathways in norepinephrine-exposed cardiac cells required investigation.
Does bucindolol reduce oxidative stress and cell death in H9c2 cardiac cells exposed to norepinephrine?
Population
H9c2 cardiac cells exposed to 10 μM norepinephrine
Comparison
Bucindolol (10 μM) for 8 h vs absence of bucindolol
Design
In vitro laboratory study
Follow-up
24 h
Authors
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May attenuate norepinephrine cardiotoxicity in experimental models; leaves open clinical translation in heart failure.
Does bucindolol reduce oxidative stress and cell death in H9c2 cardiac cells exposed to norepinephrine?
Bucindolol attenuates oxidative stress and modulates cardiac remodeling pathways in norepinephrine-exposed cardiac cells, suggesting a protective cellular mechanism.
Seolin et al. (2019) studied this question.
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