A Study of the Antifibrinolysin Activity in Human Plasmas During Pathological States 1

Utilizing the methods described in the preceding report (1), a study of the antifibrinolysin ac- tivity in plasmas from patients of Receiving and Harper Hospitals in the City of Detroit has been initiated. The antifibrinolysin in human plasma which was assayed inactivates bovine fibrinolysin. The results indicate that there is a tendency for the antifibrinolysin activity to be increased in a number of different diseases. The conditions studied include: pneumonias, coronary thrombo- sis, pernicious anemia, secondary anemia, cir- rhosis of the liver, intestinal obstructions and acute bacterial endocarditis. Other pathologies may also result in an increased plasma anti- fibrinolysin activity, although no increase was found in patients convalescing from fractures. EXPERIMENTAL