Population
Mammalian cells
Design
Preclinical
Authors
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Should not yet inform antiviral strategies; leaves open whether 3A-ER interactions drive pathogenesis in mammalian hosts.
Poliovirus protein 3A inhibits ER-to-Golgi traffic by blocking vesicle formation from the ER, independent of glycosylation.
Doedens et al. (1997) studied this question.
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