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June 22, 2016Circulation Cardiovascular ImagingOpen Access

Additive Prognostic Value of Left Ventricular Systolic Dysfunction in a Population-Based Cohort

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Key result

Low left ventricular global longitudinal strain was associated with a 128% higher risk of cardiovascular events compared to the average population risk (P<0.0001).

Why the study?

Does left ventricular global longitudinal strain (GLS) measured by 2-dimensional speckle tracking predict cardiovascular events in a population-based cohort?

Population

791 participants from a population-based cohort, mean age 50.9 years.

Design

Cohort

Follow-up

Median 7.9 years

Authors

TKTatiana KuznetsovaNational Research University Higher School of EconomicsNCNicholas CauwenberghsVrije Universiteit BrusselJKJudita KnezLjubljana University Medical Centre

Discussion

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Implication

May aid risk stratification; leaves open whether GLS-targeted interventions improve outcomes.

Study Design

Type

Cohort (n=791)

Structured PICO

Does left ventricular global longitudinal strain (GLS) measured by 2-dimensional speckle tracking predict cardiovascular events in a population-based cohort?

P
Population
791 participants from a population-based cohort (mean age 50.9 years) followed for a median of 7.9 years.
E
Exposure
Measurement of left ventricular global longitudinal strain (GLS) by 2-dimensional speckle tracking (midwall, endocardial, and epicardial).
O
Outcome
Fatal and nonfatal cardiovascular events and cardiac events at median 7.9 years follow-up.hard clinical

Main Result

p-value: p=<0.0001

Left ventricular global longitudinal strain measured by 2-dimensional speckle tracking provides additive prognostic value for future cardiovascular events beyond traditional risk factors in the general population.

Cite This Study

Kuznetsova et al. (2016) conducted a cohort in Cardiovascular risk (n=791). Low left ventricular global longitudinal strain (GLS) vs. Average population risk was evaluated on Fatal and nonfatal cardiovascular events (p=<0.0001). Low left ventricular global longitudinal strain was associated with a 128% higher risk of cardiovascular events compared to the average population risk (P<0.0001).

synapsesocial.com/papers/6a71ade08031ec7bb1dd11dahttps://doi.org/10.1161/circimaging.116.004661

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prediction of All-Cause Mortality and Heart Failure Admissions From Global Left Ventricular Longitudinal Strain in Patients With Acute Myocardial Infarction and Preserved Left Ventricular Ejection Fraction2013 · 407 citations
  2. 2Impact of Longitudinal Myocardial Deformation on the Prognosis of Chronic Heart Failure Patients2010 · 203 citations
  3. 3Myocardial strain imaging: how useful is it in clinical decision making?2015 · 889 citations
  4. 4Prognostic Value of Left Ventricular Diastolic Dysfunction in a General Population2014 · 126 citations
  5. 5Echocardiography in heart failure: applications, utility, and new horizons.2007 · 204 citations