What is the clinical evidence from this study?

Study design: Observational. Population: Atrioventricular (AV) block (n=22). Intervention: Atrioventricular block. Primary outcome: Incidence of diastolic mitral and tricuspid regurgitation.

What does this research mean for the field?

Diastolic mitral and tricuspid regurgitation occur in over 90% of patients with atrioventricular block because effective atrioventricular valve closure does not occur until ventricular systole. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 4, 2026Journal of the American College of CardiologyOpen Access

Diastolic mitral and tricuspid regurgitation by Doppler echocardiography in patients with atrioventricular block: New insight into the mechanism of atrioventricular valve closure

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Key result

Atrioventricular block is linked to diastolic mitral and tricuspid regurgitation in ~91% of patients.

n=22

Why the study?

The study prospectively determined the incidence of diastolic mitral and tricuspid regurgitation in atrioventricular block and evaluated its temporal relation to the diastolic murmur in complete heart block.

Design

Prospective observational study

Authors

ISIngela SchnittgerCardiac Imaging CAChristopher P. AppletonCardiac Imaging LHLiv K. HatleLinköping University

Discussion

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Implication

Randomized trial uncovers diastolic regurgitation in atrioventricular block, indicating flawed valve closure.

Key Points

This research aims to determine the incidence of diastolic mitral and tricuspid regurgitation in patients with atrioventricular block.
Twenty-two patients with atrioventricular block were enrolled for Doppler echocardiography analysis.
Patient age ranged from 18 to 87 years, with varying degrees of AV block.
M-mode echocardiograms were conducted to assess mitral valve closure.
Diastolic mitral regurgitation was detected in 20 patients, and tricuspid regurgitation in 21.
A mid-diastolic murmur was observed in all but three youngest patients, indicating valve flow issues.
Effective closure of the mitral valve was only achieved during ventricular systole.

Study Design

Type

Observational (n=22)

PICO

Population

22 consecutive patients aged 18 to 87 years with atrioventricular block evaluated by Doppler echocardiography.

Exposure / Comparator

Atrioventricular block

Primary Outcome

Incidence of diastolic mitral and tricuspid regurgitation

Cite This Study

Schnittger et al. (1988) conducted an observational in Atrioventricular (AV) block (n=22). Atrioventricular block was evaluated on Incidence of diastolic mitral and tricuspid regurgitation. Diastolic mitral and tricuspid regurgitation were detected by Doppler echocardiography in 91% (20/22) and 95% (21/22) of patients with atrioventricular block, respectively.

synapsesocial.com/papers/6a71ae838ebb18f5ac3fc09c https://doi.org/10.1016/0735-1097(88)90170-2

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Diastolic mitral and tricuspid regurgitation by Doppler echocardiography in patients with atrioventricular block: New insight into the mechanism of atrioventricular valve closure

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Diastolic mitral and tricuspid regurgitation by Doppler echocardiography in patients with atrioventricular block: New insight into the mechanism of atrioventricular valve closure

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

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