Key result
Angiotensin II type 1 receptor blockers may protect against ischaemic brain damage and cognitive decline partly through AT2 receptor stimulation and PPAR-gamma activation.
Why the study?
Do angiotensin II type 1 receptor blockers and AT2 receptor stimulation reduce ischaemic brain damage and improve cognitive function?
Population
Patients with or at risk for stroke, Alzheimer's disease, and dementia, as well as experimental models of…
Design
Review
Authors
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ARBs should not yet alter prescribing for neuroprotection; leaves open need for RCTs of AT2 agonism in stroke and dementia.
Do angiotensin II type 1 receptor blockers and AT2 receptor stimulation reduce ischaemic brain damage and improve cognitive function?
This review highlights the neuroprotective and cognitive benefits of ARBs, emphasizing the therapeutic potential of AT2 receptor stimulation in ischaemic brain damage.
Horiuchi et al. (2010) conducted a review in Ischaemic brain damage and cognitive function. Angiotensin II type 1 receptor blockers (ARBs) was evaluated. Angiotensin II type 1 receptor blockers may protect against ischaemic brain damage and cognitive decline partly through AT2 receptor stimulation and PPAR-gamma activation.
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