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An exceptionally useful tool in the development of novel chiral catalysts for carbonyl chemistry is the activation of carbonyl groups by double hydrogen bonding (see scheme). A diverse set of reactions such as the asymmetric Diels–Alder, hetero-Diels–Alder, aldol, and Morita–Baylis–Hillman reactions can be accelerated by such double-hydrogen-bonding catalysts.
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Petri M. Pihko (2004) studied this question.
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