Key result
Kv2 channels contribute to membrane hyperpolarization and oppose myogenic constriction in rat cerebral arteries, and their function is reduced during angiotensin II-induced hypertension.
Kv2 channels contribute to membrane hyperpolarization and oppose myogenic constriction in rat cerebral arteries, and their impaired activity may contribute to arterial dysfunction in hypertension.
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May implicate Kv2 channels in hypertensive cerebrovascular dysfunction; leaves open translation to human arteries.
Amberg et al. (2006) studied Angiotensin II-induced hypertension. Stromatoxin (Kv2 channel inhibitor) was evaluated on Kv currents and myogenic constriction. Kv2 channels contribute to membrane hyperpolarization and oppose myogenic constriction in rat cerebral arteries, and their function is reduced during angiotensin II-induced hypertension.
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