Population
Chinese hamster ovary cells expressing K(v)1.3 and K(v)3.2 channels
Comparison
Correolide and [(3)H]dihydrocorreolide (diTC) vs Mutated channels and chimeras (K(v)1.3/K(v)3.2)
Design
Preclinical
Authors
Loading...
Maps Kv1 binding sites for diTC; hypothesis-generating for selective channel modulators in cardiovascular research.
This study identifies specific regions in the S5 and S6 domains of K(v)1 channels that are necessary for high-affinity binding of correolide.
Hanner et al. (1999) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: