June 1, 1990The Journal of PhysiologyOpen Access

Tetraethylammonium blockade of apamin‐sensitive and insensitive Ca2(+)‐activated K+ channels in a pituitary cell line.

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Population

GH3 cells (pituitary cell line)

Design

Preclinical

Authors

DLDaniel G. LangResearch Triangle Park Foundation ARA K RitchieThe University of Texas Medical Branch at Galveston

Discussion

Member takes

Implication

Provides a pharmacological tool to distinguish BK and SK roles in GH3 excitability; leaves open translation to human cardiovascular tissue.

Structured PICO

Population

GH3 cells (pituitary cell line)

Intervention

Tetraethylammonium (TEA), charybdotoxin (CTX), and apamin

Outcome

Pharmacological sensitivities (dissociation constants) and physiological contributions (action potential duration and firing rate) of BK and SK channelssurrogate

In GH3 cells, BK channels contribute to action potential repolarization, whereas SK channels regulate the action potential firing rate.

Cite This Study

Lang et al. (1990) studied this question.

synapsesocial.com/papers/6a71b37bac440176ef2a4bf7 https://doi.org/10.1113/jphysiol.1990.sp018095

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Implication

Provides a pharmacological tool to distinguish BK and SK roles in GH3 excitability; leaves open translation to human cardiovascular tissue.

Tetraethylammonium blockade of apamin‐sensitive and insensitive Ca2(+)‐activated K+ channels in a pituitary cell line.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tetraethylammonium blockade of apamin‐sensitive and insensitive Ca2(+)‐activated K+ channels in a pituitary cell line.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider