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September 5, 2023Open Access

Prefrontal tDCS at 3.0mA significantly increased heart rate variability (RMSSD and HF-HRV) compared to sham and 1.5mA, demonstrating a dose-dependent effect.

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Why the study?

Prefrontal tDCS modulates the autonomic nervous system, but effects are heterogeneous and may depend on individual anatomical differences affecting brain current penetration.

Does prefrontal transcranial direct current stimulation (tDCS) improve heart rate variability in human participants?

Population

37 participants

Comparison

1.5mA vs 3mA vs sham prefrontal tDCS

Design

Randomized, double-blinded, sham-controlled within-subject trial

Key result

Prefrontal tDCS at 3.0mA significantly increased heart rate variability (RMSSD and HF-HRV) compared to sham and 1.5mA, demonstrating a dose-dependent effect.

Authors

LRLaís B. RazzaSSStefanie De SmetSNStevan Nikolin

Discussion

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Overview

Individual anatomical differences may drive heterogeneous tDCS effects on HRV; leaves open need for personalized protocols in autonomic research.

Study Design

Type

RCT (n=37)

Blinding

Double-blind

Randomization

Randomized within-subject

Structured PICO

Does prefrontal transcranial direct current stimulation (tDCS) improve heart rate variability in human participants?

P
Population
37 participants (mean age 24.3 years) who underwent three prefrontal tDCS protocols (1.5mA, 3mA, and sham) in a within-subject crossover design.
I
Intervention
Prefrontal transcranial direct current stimulation (tDCS) at 1.5mA and 3.0mA
C
Comparator
Sham tDCS
O
Outcome
Heart rate variability (HRV) measured by Root Mean Squared of Successive Differences (RMSSD) and high-frequency HRV (HF-HRV)surrogate

Cite This Study

Razza et al. (2023) reported an RCT. Prefrontal transcranial direct current stimulation (tDCS) vs. Sham was evaluated on Heart rate variability (RMSSD and HF-HRV). Prefrontal tDCS at 3.0mA significantly increased heart rate variability (RMSSD and HF-HRV) compared to sham and 1.5mA, demonstrating a dose-dependent effect.

synapsesocial.com/papers/6a71b38cce524a4339c51aaahttps://doi.org/10.22541/au.169393506.60495475/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dose‐dependent response of prefrontal transcranial direct current stimulation on the heart rate variability: An electric field modeling study2024 · 2 citations
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  4. 4Transcranial Direct Current Stimulation Modulates Resting Brain Hemodynamics and Autonomic Function: A Multimodal fNIRS-HRV Study2025
  5. 5Stress prevention by modulation of autonomic nervous system (heart rate variability): A preliminary study using transcranial direct current stimulation2012 · 10 citations