Perioperative volume replacement therapy for orthopic liver transplantation-observational, retrospective study

Aim: A significant fluid loss occurs during liver transplantation, which needs to be replaced. In this study, we analyzed whether fluid replacement strategies during liver transplantation have changed over a five-year period. Materials and methods: In this observation, retrospective study, we collected data on 155 patients who underwent liver transplantation at the University Hospital “Merkur”, 79 in 2015 and 76 in 2010. We analyzed total blood loss, total replaced fluid volume and the volume of crystalloids, colloids, erythrocyte concentrates, fresh frozen plasma and platelets applied. We employed the Student t-test for statistical analysis. Results: Total blood loss (ml) in 2015 and 2010 was 6526 ± 4194 and 11122 ± 6685, respectively, P < 0.001. Replaced fluid volume (ml) in 2015 and 2010 was the following: total fluid volume 9640 ± 6017 and 18433 ± 7282, P < 0,001; crystalline 5077 ± 1443 and 5674 ± 2326, P = 0.055; colloids 1853± 814 and 2244 ± 1188, P = 0.018; autologous blood 1097 ± 1160 and 1927 ± 2608, P = 0.011; homologous blood 1293 ± 1247 and 2979 ± 2196, P < 0.001; fresh frozen plasma 2244 ± 1523 and 5429 ± 1954, P < 0.001; platelets 349 ± 387 and 426 ± 313, P = 0.176. Conclusions: This study showed a *Dopisni autor: Dr. sc. Jadranka Pavičić Šarić, dr. med. Klinička bolnica Merkur, Odjel anestezije, reanimatologije i intenzivnog liječenja Zajčeva 19, 10000 Zagreb e-mail: jpavicic58@gmail.com Klinička bolnica Merkur, Odjel anestezije, reanimatologije i intenzivnog liječenja, Zagreb Volumna nadoknada tijekom transplantacije jetre – opservacijska, retrospektivna studija Perioperative volume replacement therapy for orthopic liver transplantation-observational, retrospective study Jadranka Pavičić Šarić*, Branislav Kocman, Denis Guštin, Jelena Zenko, Vanja Vončina, Petra Ožegović Izvorni znanstveni članak/Original scientific article