Why the study?
Does central fat distribution exacerbate diet-induced coronary artery atherosclerosis in female cynomolgus monkeys?
Population
36 female cynomolgus monkeys (Macaca fascicularis)
Comparison
High antemortem ratio of subscapular/triceps… vs Low antemortem ratio of subscapular/triceps…
Design
Preclinical
Authors
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Central fat distribution may promote atherosclerosis in female primates; supports model development but leaves human translation open.
Does central fat distribution exacerbate diet-induced coronary artery atherosclerosis in female cynomolgus monkeys?
Central fat distribution is associated with increased coronary artery atherosclerosis in female cynomolgus monkeys, suggesting they may serve as a primate model for regional fat distribution consequences in women.
Shively et al. (1987) studied this question.
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