Key result
A cluster analysis of 1,478 U.S. adults identified three subgroups based on brain health behaviors, revealing that individuals with high knowledge and good practice were older, more educated, and perceived fewer barriers.
Why the study?
At least 45% of dementia and 60% of stroke cases are attributable to modifiable risk factors, motivating characterization of knowledge and practice of healthy behaviors.
Cross-Sectional (n=1,478)
In a U.S. cohort, while knowledge of modifiable risk factors for dementia and stroke is high, the practice of corresponding healthy behaviors is lower, with socioeconomic factors and perceived barriers significantly influencing adherence.
Highlights prevention knowledge gaps in U.S. adults; leaves open impact of cluster-targeted education on dementia and stroke incidence.
At least 45% of dementia and 60% of stroke cases are due to modifiable risk factors and could in part be prevented through healthy behavior. This cross-sectional study clustered and characterized a U.S. cohort's knowledge and practice of healthy behavior associated with dementia and stroke. A total of 1,478 participants (mean age: 45.5 years, 51.8% female) were included. A hierarchical cluster analysis was performed to identify clusters based on the level of knowledge and practice of healthy behavior. We defined knowledge as recognizing eight modifiable risk factors (alcohol, diet, smoking, physical activity, sleep, stress, social relationships, and purpose in life) as important. We defined practice as complying with validated recommendations for each healthy behavior. Three clusters emerged: (I) high knowledge and poor practice (II) high knowledge and good practice, and (III) lower knowledge and poor practice. Participants in the high knowledge and good practice cluster were statistically significantly older, more educated, perceived fewer barriers (financial and time limitations), and more facilitators (motivation or knowing someone with dementia or stroke) compared to the other clusters. Our findings could assist in tailoring preventative strategies to enhance knowledge, translating knowledge into practice, and addressing particular facilitators and barriers per identified cluster.
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Senff et al. (2025) conducted a cross-sectional in Dementia and stroke prevention (n=1,478). Knowledge and practice of healthy behaviors vs. Different clusters of knowledge and practice was evaluated on Knowledge that eight modifiable risk factors contribute to keeping the brain healthy and the corresponding practice of healthy behaviors. A cluster analysis of 1,478 U.S. adults identified three subgroups based on brain health behaviors, revealing that individuals with high knowledge and good practice were older, more educated, and perceived fewer barriers.
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