Why the study?
Does graded hemorrhage and intravascular volume replacement affect systolic pressure variation and delta down in mechanically ventilated and spontaneously breathing humans?
Population
15 human subjects
Comparison
Graded hemorrhage followed by intravascular… vs Baseline measurements (repeated-measures design)
Design
Other
Authors
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May support SPV and delta down for volume assessment during mechanical ventilation; leaves open reliability in spontaneous breathing.
Does graded hemorrhage and intravascular volume replacement affect systolic pressure variation and delta down in mechanically ventilated and spontaneously breathing humans?
Systolic pressure variation and delta down are reliable indicators of intravascular volume depletion during mechanical ventilation, but are unreliable during spontaneous ventilation.
Rooke et al. (1995) studied this question.
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