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June 27, 2007Journal of Biological ChemistryOpen Access

Site-directed Mutagenesis in the B-Neuropilin-2 Domain Selectively Enhances Its Affinity to VEGF165, but Not to Semaphorin 3F

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Authors

EGElena GerettiIo Therapeutics (United States)ASAkio ShimizuSoka UniversityPKPeter KurschatUniversity Hospital Cologne

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Geretti et al. (2007) studied this question.

synapsesocial.com/papers/6a71b4fd26a7f98052ddeeadhttps://doi.org/10.1074/jbc.m702942200
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165.2000 · 22 citations
  2. 2Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins2004 · 546 citations
  3. 3Neuropilin‐1 expression by tumor cells promotes tumor angiogenesis and progression2000 · 315 citations
  4. 4Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis2002 · 374 citations