Population
Bovine aortic endothelial cells
Comparison
Low density lipoprotein 0-500 micrograms/ml for… vs Untreated cells
Design
Preclinical
Follow-up
72 hours
Authors
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Hypothesis-generating for LDL impairing endothelial NO via Gi proteins in animals; human studies needed before clinical relevance.
LDL attenuates bradykinin-stimulated release of endothelial-derived nitric oxide by preferentially inhibiting the function of Gi proteins.
James K. Liao (1994) studied this question.
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