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March 22, 2010The Journal of PhysiologyOpen Access

Ganglionic transmission in a vasomotor pathway studied in vivo

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Key result

In vivo intracellular recordings of rat sympathetic ganglion cells showed that vasoconstrictor ganglion cells mostly behave as continuously variable gates rather than 1:1 relays.

Population

40 spontaneously active cells in the third lumbar sympathetic ganglion of urethane-anaesthetized rats

Design

Preclinical

Authors

BBBradford O. BrattonFlorey Institute of Neuroscience and Mental HealthPDPhilip DaviesIS Instruments (United Kingdom)WJWilfrid JänigUppsala University Hospital

Discussion

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Implication

No immediate clinical implications; leaves open whether variable gating applies to human sympathetic vasomotor control.

Structured PICO

P
Population
Intracellular recordings from 40 spontaneously active cells in the third lumbar sympathetic ganglion of urethane-anaesthetized rats.
E
Exposure
Intracellular recordings in vivo
O
Outcome
Action potential firing rates, excitatory postsynaptic potential (EPSP) amplitudes, and cardiac rhythmicity modulationsurrogate

Vasoconstrictor ganglion cells in vivo function as continuously variable gates rather than simple 1:1 relays.

Cite This Study

Bratton et al. (2010) studied this question. Intracellular recordings of ganglionic transmission was evaluated on Action potential firing and EPSP characteristics. In vivo intracellular recordings of rat sympathetic ganglion cells showed that vasoconstrictor ganglion cells mostly behave as continuously variable gates rather than 1:1 relays.

synapsesocial.com/papers/6a71b64e6c240de38cdc3572https://doi.org/10.1113/jphysiol.2009.185025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reflex patterns in postganglionic neurons supplying skin and skeletal muscle of the rat hindlimb1994 · 74 citations
  2. 2The discharge behaviour of single vasoconstrictor motoneurones in human muscle nerves.1994 · 250 citations
  3. 3Integrative Action of the Autonomic Nervous System: Neurobiology of Homeostasis2006 · 356 citations
  4. 4Analysis of the periodicity of synaptic events in neurones in the superior cervical ganglion of anaesthetized rats1998 · 32 citations
  5. 5Rectification of synaptic and acetylcholine currents in the mouse submandibular ganglion cells.1989 · 42 citations