Key result
Adiponectin was associated with a lower risk of pre-existing stroke (OR 0.64; 95% CI 0.46-0.88; p<0.01), whereas leptin, resistin, and visfatin were associated with a higher risk.
Why the study?
Obesity is reported to increase stroke risk with adipokines implicated as mediators, but the relationship between adipokines and stroke is not well clarified.
Are adipokine levels associated with the risk of stroke and subsequent patient outcomes?
Meta-Analysis (n=62,428)
Are adipokine levels associated with the risk of stroke and subsequent patient outcomes?
Odds Ratio: 0.64 (95% CI 0.46–0.88)
p-value: p=<0.01
Adipokines are associated with the risk of pre-existing stroke and may serve as biomarkers for stroke severity and 6-month mortality.
Supports adipokines as stroke biomarkers; hypothesis-generating for causality and requires prospective validation before clinical adoption.
Obesity is reported to increase stroke risk, with adipocyte-derived cytokines or adipokines implicated as mediators. However, the relationship between adipokines and stroke is not well clarified. Thus, we aimed to evaluate the association of adipokines with stroke using fully adjusted risk estimates that incorporated body mass index in a meta-analysis. Data from 52 studies (62,428 patients) were pooled in a random-effects meta-analysis. Adiponectin was independently associated with a lower risk of pre-existing stroke (adjusted odds ratio: 0.64 [95% confidence interval: 0.46-0.88], p < 0.01), whereas leptin (1.08 [1.00-1.17], p = 0.04), resistin (1.06 [1.04-1.08], p < 0.01) and visfatin (1.04 [1.01-1.07], p = 0.01) are associated with a higher risk of stroke, but none with incident stroke. Adipokines independently associated with an ischaemic stroke subtype were adiponectin (0.48 [0.30-0.77], p < 0.01), leptin (1.10 [1.01-1.20], p = 0.04), and resistin (1.06 [1.04-1.08], p < 0.01). Fatty acid-binding protein-4 (FABP-4) independently predicted 6-month poor functional outcomes in stroke patients (adjusted hazard ratio: 1.09 [1.06-1.12], p < 0.01); whereas both FABP-4 (1.17 [1.03-1.34], p = 0.01) and visfatin (1.24 [1.00-1.55], p = 0.05) were predictive of 6-month mortality. Adipokines are associated with a greater risk of pre-existing stroke, but not with the relationship with incident stroke. Adipokines, such as FABP-4 and visfatin, may serve as biomarkers of stroke severity and worsening of stroke outcomes.
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Agbaedeng et al. (2024) conducted a meta-analysis in stroke (n=62,428). Adipokines was evaluated on pre-existing stroke (OR 0.64, 95% CI 0.46-0.88, p=<0.01). Adiponectin was associated with a lower risk of pre-existing stroke (OR 0.64; 95% CI 0.46-0.88; p<0.01), whereas leptin, resistin, and visfatin were associated with a higher risk.
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