Key result
The cardio-ankle vascular index was significantly and positively correlated with the pulsatility index of the common carotid artery (r = 0.44, P < 0.001) in patients with cardiovascular risk factors.
Why the study?
Increased common carotid artery pulsatility index is linked to ischemic stroke, but its relationship with the cardio-ankle vascular index in patients with cardiovascular risk factors needed clarification.
Does the cardio-ankle vascular index (CAVI) correlate with the pulsatility index (PI) of the common carotid artery in patients with cardiovascular risk factors?
Cross-Sectional (n=405)
No
Does the cardio-ankle vascular index (CAVI) correlate with the pulsatility index (PI) of the common carotid artery in patients with cardiovascular risk factors?
In patients with cardiovascular risk factors, the cardio-ankle vascular index (CAVI) is independently associated with the pulsatility index of the common carotid artery, suggesting it reflects cerebrovascular resistance and may help identify patients at higher risk for ischemic stroke.
Observed link between stiffness and carotid pulsatility is hypothesis-generating; does not support practice change.
BACKGROUND: Pulsatility index (PI) is a hemodynamic parameter determined using Doppler sonography; it reflects the degree of peripheral vascular resistance. Moreover, researchers have reported significant relationships between an increase in the PI of the common carotid artery (CCA) and ischemic stroke. This cross-sectional study aimed to clarify the relationships between cardio-ankle vascular index (CAVI) as a marker of arterial stiffness and the PI of the CCA in patients with cardiovascular risk factors for the primary prevention of ischemic stroke. METHODS: A total of 405 outpatients undergoing treatment for cardiovascular risk factors (152 men and 253 women; mean age ± standard deviation, 64 ± 9 years) with no history of cardiovascular events, including ischemic stroke, were enrolled. The CAVI and the PI of the CCA were measured using commercial devices, and their relationships to various clinical parameters were examined. RESULTS: A significant positive correlation was observed between the CAVI and the PI of the CCA (r = 0.44, P < 0.001). Further, multiple regression analysis revealed that the CAVI (β = 0.19, P < 0.001) was selected as independent factor for PI of the CCA as a subordinate factor. Meanwhile, high-sensitivity C-reactive protein, as an inflammation marker, and skin autofluorescence, as a marker of advanced glycation end products in the tissues, were selected as independent variables for either the CAVI or the PI of the CCA as a subordinate factor. The receiver-operating characteristic curve analysis indicated that the cut-off point of the CAVI for high PI of the CCA (> 1.60) as a risk value of stroke incidence by previous report was 9.1 (area under the curve = 0.750, P < 0.001). CONCLUSION: The present results indicate that the CAVI reflects cerebrovascular resistance in patients with cardiovascular risk factors. Moreover, the risk value of the CAVI for ischemic stroke incidence was considered to be 9.1 in these patients.
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Takashi Hitsumoto (2019) conducted a cross-sectional in Cardiovascular risk factors (n=405). Cardio-ankle vascular index (CAVI) was evaluated on Correlation between CAVI and PI of the CCA (r = 0.44, p=<0.001). The cardio-ankle vascular index was significantly and positively correlated with the pulsatility index of the common carotid artery (r = 0.44, P < 0.001) in patients with cardiovascular risk factors.
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