Key result
Dyslipidemia significantly increased cardio-ankle vascular index values compared to healthy controls (8.08 vs 7.11, p<0.01), indicating higher arterial stiffness even in the absence of diabetes or hypertension.
Why the study?
Does dyslipidemia increase the cardio-ankle vascular index (CAVI) in patients without diabetes or hypertension compared to healthy controls?
Cross-Sectional (n=785)
No
Does dyslipidemia increase the cardio-ankle vascular index (CAVI) in patients without diabetes or hypertension compared to healthy controls?
Absolute Event Rate: 8.08% vs 7.11%
p-value: p=<0.01
Dyslipidemia is independently associated with increased arterial stiffness, as measured by the cardio-ankle vascular index (CAVI), even in the absence of diabetes and hypertension.
Dyslipidemia may independently increase arterial stiffness; hypothesis-generating for CAVI monitoring and requires prospective validation before practice change.
AIM: The cardio-ankle vascular index (CAVI) is a sensitive non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to compare the CAVI values in patients with dyslipidemia (without diabetes mellitus and hypertension) and healthy controls. METHODS: A Total 248 subjects with dyslipidemia (104 men, 144 women), 55.0 (95% CI 30-70) years of age with combined hyperlipidemia or primary hypercholesterolemia and 537 healthy controls (244 men, 293 women) 40.0 (95% CI 26-62) years of age were included in this study. Fasting blood samples were collected to measure the serum total cholesterol, triglyceride, HDL-cholesterol and apolipoprotein A1 and B levels. The LDL cholesterol level was also calculated, and the CAVI was measured using the VaSera(®) 1500 system. RESULTS: The CAVI values were significantly higher in the dyslipidemic patients (8.08, 95% CI 6.00-10.05) than in the controls (7.11, 95% CI 5.77-9.05; p < 0.01). In addition, the CAVI values were elevated in both subgroups of patients with hypercholesterolemia (7.95, 95% CI 5.85-6.90; p < 0.01) and combined hyperlipidemia (8.30, 95% CI 6.60-10.15; p < 0.01) in comparison with those observed in the controls. After adopting the propensity score method in order to balance the confounding factors (age, gender, body mass index) and adjust the analysis for diastolic blood pressure, the CAVI values in the dyslipidemic patients remained significantly high (7.78, 95% CI 5.80-9.69) compared to that observed in the controls (7.31, 95% CI 5.44-9.35; p < 0.001). However, the CAVI values did not differ significantly between the controls and both subgroups of dyslipidemic patients(primary hypercholesterolemia, combined hyperlipidemia). CONCLUSIONS: The present findings demonstrated that dyslipidemia increases the CAVI values in comparison to that seen in healthy subjects.
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Dobšák et al. (2014) conducted a cross-sectional in Dyslipidemia without diabetes or hypertension (n=785). Dyslipidemia vs. Healthy controls was evaluated on Cardio-ankle vascular index (CAVI) (p=<0.01). Dyslipidemia significantly increased cardio-ankle vascular index values compared to healthy controls (8.08 vs 7.11, p<0.01), indicating higher arterial stiffness even in the absence of diabetes or hypertension.