Key result
Serum LDL-C and non-HDL-C concentrations were negatively associated with the cardio-ankle vascular index (CAVI) in nonrisk groups, such as nondiabetics or patients with maxIMT <1.0 mm.
Why the study?
Is there an association between arterial stiffness evaluated by CAVI and serum LDL-C concentrations in patients undergoing general health checkups?
Cross-Sectional (n=1,878)
Is there an association between arterial stiffness evaluated by CAVI and serum LDL-C concentrations in patients undergoing general health checkups?
In early-stage atherosclerosis, there is a negative association between arterial stiffness measured by CAVI and serum LDL-C levels, which is absent in higher-risk patients.
Should not change lipid management in low-risk patients; leaves open mechanisms of negative LDL-C–CAVI link in early atherosclerosis.
The cardio-ankle vascular index (CAVI), calculated values from cardio-ankle pulse wave velocity and blood pressure, corresponds predominantly to the stiffness of the aorta and peripheral arteries of the lower limbs. However, the reported associations between CAVI and serum low-density lipoprotein cholesterol (LDL-C) levels remain inconsistent. A cross-sectional study of 1878 consecutive patients (mean age: 59.2 years) who underwent general health checkup showed a negative association between CAVI and serum LDL-C or non-high-density lipoprotein cholesterol (non-HDL-C) concentrations with age-adjusted correlation and multiple regression analysis. Using the similar analyses divided by the status of risk factors and degree of maximum carotid intima-media thickness (maxIMT), negative correlations between CAVI and LDL-C or non-HDL-C levels were observed only in nonrisk groups including nondiabetics patients or patients with maxIMT <1.0 mm, in those with expected low extent of advanced atherosclerotic lesions. In contrast, such a correlation was not found in each comparable risk-loaded group.
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Homma et al. (2014) conducted a cross-sectional in Early-stage atherosclerosis (n=1,878). Serum low-density lipoprotein cholesterol (LDL-C) concentration was evaluated on Association between CAVI and serum LDL-C or non-HDL-C concentrations. Serum LDL-C and non-HDL-C concentrations were negatively associated with the cardio-ankle vascular index (CAVI) in nonrisk groups, such as nondiabetics or patients with maxIMT <1.0 mm.
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