Key result
Qingda granule treatment attenuated elevated blood pressure and promoted vasorelaxation of thoracic aortic rings by inhibiting calcium influx and activating the AKT pathway in hypertensive rats.
Why the study?
Qingda granule has been used to treat hypertension, but its molecular mechanisms in antihypertension remain largely unknown.
Does Qingda granule treatment reduce elevated blood pressure in spontaneously hypertensive rats?
Does Qingda granule treatment reduce elevated blood pressure in spontaneously hypertensive rats?
Qingda granules demonstrate antihypertensive and vasodilatory effects in preclinical models via calcium channel inhibition and AKT pathway modulation.
Hypothesis-generating for Qingda granule in hypertension; human trials needed before clinical consideration.
The Qingda granule (QDG) formulation was simplified from the Qingxuan Jiangya Decoction, which has been used in China to treat hypertension for decades. However, the molecular mechanisms of QDG in antihypertension remain largely unknown. Therefore, we evaluated the therapeutic efficacy of QDG against elevated blood pressure and explored its underlying mechanism. QDG treatment decreased elevated blood pressure and increased the vascular elasticity of thoracic aortic rings to KCl stimulation in spontaneously hypertensive rats. QDG treatment increased the relaxation of isolated thoracic aortic rings precontracted with norepinephrine (NE) or KCl in an endothelium-independent manner, which was attenuated by treatment with verapamil, but not by treatment with TEA, 4-AP, Gli, or BaCl2. Moreover, QDG pretreatment attenuated the CaCl2-induced constriction of isolated thoracic aortic rings in K- or NE-containing Ca-free solutions. In addition, QDG pretreatment significantly inhibited the influx of Ca in A7r5 cells induced by a K- or NE-containing Ca solution and decreased the levels of p-AKT but had no effect on levels of total AKT protein in isolated thoracic aortic rings. Considering these results, QDG treatment attenuated elevated blood pressure and promoted the vasorelaxation of thoracic aortic rings by inhibiting the influx of Ca and activating the AKT pathway.
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Huang et al. (2019) studied Hypertension. Qingda granules (QDG) was evaluated on Blood pressure, vascular elasticity, vasorelaxation, calcium influx, and AKT pathway protein levels. Qingda granule treatment attenuated elevated blood pressure and promoted vasorelaxation of thoracic aortic rings by inhibiting calcium influx and activating the AKT pathway in hypertensive rats.
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