Why the study?
Does physical exercise improve flow-mediated dilatation of skeletal muscle arteries in rats with chronic heart failure?
Population
Rats with chronic heart failure (induced by coronary artery ligation) and sham-operated rats
Comparison
Physical exercise vs Sedentary rats (both CHF and sham)
Design
Preclinical
Follow-up
10 weeks
Authors
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Does not yet alter heart failure management; extends mechanistic evidence for exercise on skeletal muscle FMD in animal models.
Does physical exercise improve flow-mediated dilatation of skeletal muscle arteries in rats with chronic heart failure?
In a rat model of chronic heart failure, exercise partially restores flow-mediated dilatation of small skeletal muscle arteries by improving the nitric oxide pathway and reducing oxidant stress.
Varin et al. (1999) studied this question.
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