Key result
Intramyocardial injection of Ad5/iNOS in mice markedly reduced infarct size, providing cardioprotection equivalent to late preconditioning via a COX-2-dependent mechanism.
Authors
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Should not change clinical practice for myocardial infarction; leaves open translation of iNOS gene therapy to human cardioprotection.
Li et al. (2003) studied Myocardial infarction. Ad5/iNOS gene transfer was evaluated on Infarct size. Intramyocardial injection of Ad5/iNOS in mice markedly reduced infarct size, providing cardioprotection equivalent to late preconditioning via a COX-2-dependent mechanism.
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