The novel seated-position stiffness index (iCAVI) showed modest diagnostic discrimination for coronary artery disease (AUC 0.630), similar to conventional CAVI (AUC 0.591).
Observational (n=121)
No
Does the seated-position innovative CAVI (iCAVI) provide comparable diagnostic performance for CAD and reproducibility as the conventional supine CAVI in outpatients with cardiovascular risk factors?
The novel seated-position iCAVI provides comparable reproducibility and modest diagnostic discrimination for CAD as the conventional supine CAVI, potentially facilitating easier clinical and home-based arterial stiffness monitoring.
Absolute Event Rate: 0.63% vs 0.591%
BACKGROUND: The cardio-ankle vascular index (CAVI) is a widely used noninvasive marker of arterial stiffness that is independent of blood pressure at the time of measurement. However, its requirement for supine positioning limits practicality in certain settings. This study aimed to evaluate the feasibility and clinical utility of a novel seated-position stiffness index, termed the innovative CAVI (iCAVI), measured from the aortic valve to the brachial artery in assessing arterial stiffness. METHODS: We enrolled 121 outpatients with cardiovascular risk factors. Participants were divided into groups with and without coronary artery disease (CAD). All CAD participants had previously undergone percutaneous coronary intervention at our department at least 3 months before enrollment and were in stable outpatient follow-up. Reproducibility, correlations with clinical parameters, and diagnostic performance for CAD were assessed. RESULTS: The cohort included 63 CAD-positive and 58 CAD-negative patients. Both CAVI and iCAVI showed high intraobserver reproducibility (ρ = 0.937 and 0.895; P < .001). iCAVI correlated with CAVI (ρ = 0.481; P < .001). Diagnostic discrimination for CAD was modest and similar between indices: area under the curve 0.630 for iCAVI and 0.591 for CAVI. Optimal cutoffs were 2.95 (iCAVI) and 10.40 (CAVI). In sensitivity analyses, iCAVI showed no significant association with measurement-time SBP or DBP, in contrast to heart-brachial pulse wave velocity. CONCLUSIONS: In this single-center cohort, iCAVI showed modest discrimination for CAD, similar to conventional CAVI, while enabling seated measurement. The development of a dedicated device-akin to a home blood pressure monitor-could facilitate clinical implementation and support day-to-day health management.
Shimizu et al. (Fri,) conducted a observational in Coronary artery disease (n=121). innovative CAVI (iCAVI) vs. conventional CAVI was evaluated on Diagnostic discrimination for coronary artery disease (Area under the curve). The novel seated-position stiffness index (iCAVI) showed modest diagnostic discrimination for coronary artery disease (AUC 0.630), similar to conventional CAVI (AUC 0.591).