Why the study?
Does the duration of pressure overload affect the regression speed of cardiac MHC isozyme V3 after relief of the load in rats?
Population
Rats subjected to right or left ventricular pressure overload for 1 or 3 weeks, and sham-operated controls
Comparison
Relief of pressure overload vs Sham-operated controls
Design
Preclinical
Follow-up
Up to 10 weeks after relief of overload
Authors
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Overload duration may modulate MHC isoform recovery kinetics in rat RV; leaves open translation to human remodeling.
Does the duration of pressure overload affect the regression speed of cardiac MHC isozyme V3 after relief of the load in rats?
The regression speed of the cardiac MHC isoform V3 after relief of pressure overload is dependent on the duration of the preceding overload, with right and left ventricles showing different responsiveness.
Imamura et al. (1996) studied this question.
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